运动员服用类固醇类固醇剂的血液参数异常; 一项观察性临床研究
Ghaida Siraj Mubarak1, Ghazi A Bamagous2, Safaa M Alsanosi2
1Pharmacy Department, Hera' General Hospital, Ministry of Health, Makkah, Saudi Arabia.
运动员使用类固醇类固醇 (AAS),通常与其他物质结合使用,会导致显著的不良影响. 血液测试显示了荷尔蒙失衡和肝酶升高,突显了非治疗性AAS使用的风险.
科学领域:
- 内分泌学 在内分泌学.
- 运动医学 运动医学
- 毒理学 毒理学 毒理学
背景情况:
- 类固醇类固醇 (AAS) 广泛用于运动增强,尽管已知存在严重副作用的风险.
- 以前的研究还没有广泛评估AAS使用者的直接血液参数变化.
- 这项研究旨在调查AAS相关的不良影响及其对运动员血液标志物的影响.
研究的目的:
- 为了研究在运动员中使用合成安卓类固醇 (AAS) 的不良影响.
- 为了确定AAS使用是否与血液参数的特定变化相关.
- 评估AAS用户中副作用和医疗诊断的流行情况.
主要方法:
- 一项观察性研究,涉及在线问卷和实验室血液检测.
- 参与者 (n=31) 提供了社会人口统计数据以及关于AAS和补充剂使用的信息.
- 血液样本被分析为荷尔蒙和生化标志物.
主要成果:
- 94%的参与者使用非治疗目的的AAS,通常是组合 (96%的AAS,74%的其他补充剂).
- 通常报告的副作用 (74%) 和医学诊断 (28%) 包括高血压,高脂血症和不孕症.
- 观察到的血液变化包括高丸激素,益生素,ALT,AST,脂质样本以及低LH和FSH水平.
结论:
- 单独或与其他物质一起使用无监督的AAS与不良健康结果有关.
- 血液参数的显著变化表明潜在的长期健康风险.
- 需要对更大的队列进行进一步研究,以确定关于AAS安全性的最终结论.
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