在非酒精性脂肪肝疾病中补充亚麻粉:一项随机对照临床试验
Yanyan Tian1, Yuhao Zhou1, Wang Liao1
1Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China. yangligang2012@163.com.
Food & function
|January 29, 2025
概括
在非酒精性脂肪性肝病 (NAFLD) 患者中,为期12周的亚麻粉补充剂有效降低了肝脂肪,改善了代谢健康. 这种饮食干预也积极调节了肠道微生物群的组成,突出的是亚麻.
科学领域:
- 肝病学和胃肠道学
- 营养科学 营养科学
- 微生物组研究 微生物组研究
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 是一个全球性的健康问题,饮食干预措施显示出希望.
- 以前的研究表明,在NAFLD的动物模型中,亚麻具有有益的影响.
研究的目的:
- 评估亚麻粉在改善诊断为NAFLD的患者的肝脂含量的疗效.
- 评估亚麻对身体组成,肝功能和葡萄脂代谢的影响.
主要方法:
- 一个为期12周的随机对照试验,涉及50名NAFLD患者.
- 参与者被分配到亚麻种粉末组 (30克/天) 或对照组,两者都接受健康教育.
- 主要结局:通过MRI测量肝脏内脂含量;次要结局:身体组成,肝功能测试和代谢参数.
主要成果:
- 亚麻种群显著减少了肝脏脂肪,身体脂肪百分比,肥胖指数和内脏脂肪面积.
- 在肝功能标志物 (TBIL,DBIL,IBIL,AST) 和脂质谱 (TC,TG,Apo A1,HDL-C) 中观察到显著改善.
- 亚麻干预改变了肠道微生物群,增加了有益的细菌 (例如,Bacteroides,Bifidobacterium) 并减少了有害的细菌.
结论:
- 在12周的亚麻粉补充剂有效改善了NAFLD患者的肝脂沉积,肝功能,身体组成和脂质代谢.
- 亚麻积极调节肠道微生物群,增加有益的细菌,减少有害的细菌.
- 亚麻是一种天然和有效的饮食选择,用于管理NAFLD.
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