确定皮肤和软组织感染的最佳抗生素持续时间
1Department of Medicine, Clínica Rotger Quironsalud, Palma de Mallorca, Spain.
Current opinion in infectious diseases
|January 29, 2025
概括
较短的抗生素持续时间对皮肤和软组织感染 (SSTI) 越来越有效. 目前的做法往往涉及长时间的治疗,突出显示了SSTI抗生素管理方面的差距.
科学领域:
- 传染性疾病 传染性疾病
- 抗微生物药物管理委员会
- 皮肤病学 皮肤病学
背景情况:
- 皮肤和软组织感染 (SSTI) 的最佳抗生素持续时间尚不清楚.
- 最近的文献综述侧重于影响SSTI治疗持续时间的临床实践的进展.
- 抗生素管理是改善SSTI管理的关键领域.
研究的目的:
- 审查了解选择性SSTI的最佳抗生素治疗持续时间的最新进展.
- 评估有关SSTI治疗持续时间的新知识对临床实践的影响.
- 确定改善SSTI管理中的抗生素管理的机会.
主要方法:
- 系统审查过去18个月发表的文献.
- 分析美国的临床实践模式,并推断到其他地区.
- 评估有关腹大小,肥胖,糖尿病足部感染和死软组织感染的证据.
主要成果:
- 很少有患者接受符合指导方针的抗生素治疗.
- 腹大小与在排水后的SSTI中治愈没有直接关联.
- 较短的抗生素持续时间显示在肥胖患者,糖尿病足部感染 (高达6周的骨髓炎) 和死软组织感染 (大约48小时后源控制) 中有效.
结论:
- 越来越多的证据支持各种SSTI的治疗时间更短.
- 现实世界的临床实践往往偏离,长期治疗仍然很常见.
- 针对SSTI的个性化治疗方法需要进一步研究.
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