麻疹:麻疹根除后的出现,正在进行的疫情和预防策略
Amy E Bryant1, Stanford T Shulman2
1Idaho State University, Meridian, Idaho.
Current opinion in infectious diseases
|January 29, 2025
概括
麻疹根除工作的结束可能有助于麻疹疫情爆发. 目前的第I类mopox疫情突出显示,需要更新针对orthopoxvirus的疫苗和预防策略.
科学领域:
- 流行病学 流行病学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 全球天花根除计划的终止与mopox.的出现相吻合.
- 包括2022年第II类和2024年正在进行的第I类事件在内的Mpox疫情构成了重大公共卫生挑战.
研究的目的:
- 检查天花根除工作与天花发病率之间的联系.
- 审查2022年mopox流行病和当前的Clade I爆发.
- 讨论mpox.病毒的病毒演变,病变和预防策略.
主要方法:
- 查看天花根除与mopox之间的时间关联.
- 对最近爆发的Mopox疫情 (Clade IIb和Clade Ib) 的分析.
- 评估当前和新兴的MOPOX预防和诊断工具.
主要成果:
- 类IIbmopox病毒 (MPXV) -2022表现出潜在增强传播能力和严重性的遗传变化.
- 非洲正在爆发一种更具毒性的clade Ib MPXV菌株的持续爆发,并在全球传播.
- 世界卫生组织宣布mopox成为全球卫生紧急情况.
结论:
- 小天花疫苗接种提供了对mpox的交叉保护.
- 脊髓灰质炎根除后群体免疫力下降有助于脊髓灰质炎流行.
- 虽然天花疫苗是有效的,但新的mRNA疫苗对未来的脊髓灰质炎病毒预防有希望.
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