接受术前治疗 (EMPT前) 的食道恶性病患者的预康复:来自前性受控试验的结果
R Bott1, J Zylstra1,2, W Knight1
1Department of Upper GI and General Surgery, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Journal of surgical oncology
|January 29, 2025
概括
在新辅助化疗和手术前的结构化炼改善了食道腺癌患者的健康状况和化疗反应. 这种预康复计划缓解了心肺衰退,并减少了缩症和淋巴缺血症.
科学领域:
- 在瘤学瘤学.
- 心肺生理学 心肺生理学
- 运动科学 运动科学
背景情况:
- 新辅助化疗 (NAC) 和食管切除术显著影响患者的健康和生活质量.
- 前EMPT研究研究了结构化炼在减轻这些不良影响方面的有效性.
研究的目的:
- 评估结构化预康复运动计划是否可以减少停留时间,术后并发症,并改善NAC和食道切除术的患者的健康和健康相关生活质量 (HRQL).
- 评估预康复对心肺功能,身体组成和免疫标记物的影响.
主要方法:
- 一项前性非随机试验将标准护理途径 (对照) 与在NAC和食道腺癌手术之前启动的结构化预康复运动计划 (干预) 进行了比较.
- 收集的数据包括住院时间,术后并发症,心肺运动测试 (CPEX),身体组成,淋巴细胞水平和HRQL问卷.
主要成果:
- 虽然住院时间长度相似,但干预组显示出较少并发症的趋势 (6对11).
- 在干预组中,心肺健康 (VO2峰值) 的下降较小 (-13.54% vs -21.40%,p=0.02).
- 干预组表现出身体组成的改善 (p=0.043),提高了表现,认知,睡眠和情绪功能,增加了淋巴细胞子集 (p=0.034),以及改善了化疗反应 (p=0.022).
结论:
- 结构化的运动计划可以有效地减轻食道癌的NAC期间心肺脱水的情况.
- 预康复可能会减少肉症和抵消化疗引起的淋巴缺血症.
- 运动干预措施在改善NAC和食道切除术的患者的功能结果和治疗反应方面表现有希望.
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