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纳米材料和临床SERS技术:在疾病诊断中的广泛应用

Ifeanyichukwu Michael Onyemaobi^1,2,3, Yujiao Xie^1,3, Jiahao Zhang^1,3

¹Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Laboratory of Advanced Theranostic Materials and Technology, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China. aiguo@nimte.ac.cn.

Journal of materials chemistry. B

|January 29, 2025

概括

表面增强拉曼光谱 (SERS) 为快速癌症检测提供了有前途的诊断方法. 纳米结构材料 (NMs-SERS) 提高了灵敏度和特异性,促进了癌症等疾病的临床应用.

科学领域:

分析化学分析化学
生物医学科学生物医学科学
物理物理学物理

背景情况:

由于医疗保健的挑战和诊断时间的限制,越来越需要快速诊断癌症.
表面增强拉曼光谱 (SERS) 显示出对用户友好型诊断的承诺.
用于SERS的纳米结构材料 (NMs-SERS) 已经证明了显著的灵敏度和特异性.

研究的目的:

审查临床SERS诊断方面的进展.
强调NMS-SERS在瘤诊断中的作用,特别是在循环瘤细胞 (CTC) 中.
讨论微流体学,Ramanomics和AI的整合,以进行增强的SERS分析.

主要方法:

研究了SERS的电磁 (EM) 和化学 (CM) 增强原理.
专注于NMS-SERS特征:表面电荷,形状,尺寸,灵敏度,特异性,可重复性和可回收性.
检查了用于CTC隔离的微流体芯片和用于数据分析的AI.

主要成果:

NMs-SERS在生物医学瘤诊断,特别是CTC识别方面取得了重大进展.
在SERS的运行原则的基础上,有互补的EM和CM效应.
除了概念验证研究之外,有限的翻译SERS应用.

结论:

特别是与NMS-SERS一起的SERS,具有精确诊断慢性疾病的潜力.
微流体学,Ramanomics和AI的整合可以加强SERS数据分析.
需要进一步开发以加快SERS诊断的临床翻译.

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