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Updated: May 30, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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探索胺基金基皮科普拉丁的结构-活性关系 (IV) 产药

Martijn Dijkstra1,2, Hemma Schueffl3, Barbora Adamova3

  • 1Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.

Inorganic chemistry
|January 29, 2025
PubMed
概括

合成了新的 (II) 和 (IV) 前药,以改善癌症治疗. 胺结合增强了瘤积累,但只有一些衍生品显示出显著的瘤生长抑制,这表明重的配体可能会阻碍白金 (IV) 前药激活.

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