通过抗氧化机制通过纳米库尔库明改善的cypermethrin的脏毒性作用
Saeed Alshahrani1, Mohammad Ashafaq1, Abdulmajeed M Jali1
1Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, 45142, Jazan, Saudi Arabia.
Naunyn-Schmiedeberg's archives of pharmacology
|January 29, 2025
概括
纳米库尔库 (NC) 通过减少氧化应激和炎症来减轻甲诱导的损伤. 这项研究表明NCNC.
科学领域:
- 毒理学 毒理学 毒理学
- 纳米技术 纳米技术
- 生物化学 生物化学
背景情况:
- 甲 (Cyp) 是一种类杀虫剂,通过氧化应激,炎症和亡诱导毒性.
- 氧化剂和抗氧化剂之间的不平衡会加剧Cyp引起的损伤.
- 纳米库尔库 (NC) 具有增强的生物可用性,具有抗氧化和抗炎性质.
研究的目的:
- 为了研究纳米库尔库明 (NC) 对甲 (Cyp) 诱导的脏毒性对大鼠的保护作用.
- 评估NC对氧化应激,炎症和亡标志物的影响.
- 为了确定NC的最佳剂量,以减轻Cyp的毒性.
主要方法:
- 鼠被分为接受控制的组,单独使用NC,单独使用Cyp或使用不同剂量NC的Cyp.
- 口服治疗进行了两周的时间.
- 通过测量脂质过氧化 (LPO),4-氨酸 (4-HNE),谷氨酸 (GSH),催化酶和超氧化物脱酶 (SOD) 来评估功能.
- 使用ELISA,qRT-PCR和组织病理学来评估炎症和亡,重点关注NF-kB,Bax,caspase-3和caspase-9等标记物.
主要成果:
- 治疗显著增加了氧化应激标志物 (LPO,4-HNE),炎症性白内素和亡标志物 (Bax,NF-kB,caspase-3,caspase-9).
- 同时治疗的NC剂量依赖性降低了LPO和4-HNE水平,表明氧化应激降低.
- NC的使用改善了抗氧化剂状态 (GSH,甲酶,SOD) 并改善了炎症和亡途径,这可以通过减少NF-kB,Bax,caspase-3和caspase-9的表达来证明.
- 组织病理学检查证实NC治疗组的损伤减少.
结论:
- 在老鼠中,纳米库尔库有效地改善了甲诱导的毒性.
- 通过减少氧化应激,炎症和亡,NC可以减轻损伤.
- 作为防护剂,NC显示出重要的潜力,可以防止甲状腺杀虫剂的毒性.
关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.甲 (Cypermethrin) 是一种甲 (Cypermethrin) 的一种.炎症 炎症是一种炎症.纳米库尔库明是一种纳米.毒性 毒性 毒性氧化应激是一种氧化应激.更多相关视频
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