腹部LIPUS刺激通过调节肠道微生物群来防止后肢不负荷的小鼠的认知衰退
Yumei Zheng1, Yanan Yu1, Mengyao Chen1
1Institute of Sports Biology, Shaanxi Normal University, Xi'an, 710119, China.
Molecular neurobiology
|January 29, 2025
概括
低强度脉冲超声波 (LIPUS) 在模拟无重量状态下改善肠道健康和认知功能. 这种超声波疗法恢复肠道微生物群,增强学习和记忆力,为宇航员和卧床患者提供潜在的好处.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 生物医学工程 生物医学工程
背景情况:
- 体重不足会破坏肠道微生物群,并损害认知功能,肠道健康和神经疾病之间已知存在联系.
- 低强度脉冲超声波 (LIPUS) 显示出抗炎作用,特别是在肠道.
研究的目的:
- 调查腹部LIPUS刺激是否可以通过解决肠道功能障碍来减轻无重感引起的认知衰退.
主要方法:
- 使用后肢卸载的小鼠来模拟无重量状态,其中一些接受了腹部LIPUS治疗.
- 评估了肠道结构,肠道微生物组成,血清脂多糖 (LPS),短链脂肪酸 (SCFA) 和认知行为.
- 分析了紧结蛋白的表达,海马中的神经适应相关蛋白和便微生物群移植.
主要成果:
- 后肢卸载导致肠道干扰,肠道微生物群的改变,以及学习/记忆障碍.
- LIPUS治疗改善了肠道完整性 (增加了ZO-1,Occludin),恢复了肠道微生物多样性,减少了LPS,增加了SCFA.
- 接受LIPUS治疗的小鼠表现出增强的认知功能,改善的探索行为,以及增加的海马神经可塑性标志物 (PSD95,BDNF等). ) 的情况.
- 来自LIPUS治疗小鼠的便微生物群移植也改善了接受小鼠的认知功能和肠道结构.
结论:
- 腹部LIPUS治疗有效地改善了肠道结构和微生物群的平衡,从而减轻了无重量感应的认知障碍.
- 在诸如太空飞行或长时间的床上休息等条件下,LIPUS为管理肠道功能障碍和认知衰退提供了一个有前途的治疗策略.
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