对肥胖药物使用和公众意识的纵向分析
Philipp Berning1, Rishav Adhikari1, Adrian E Schroer1
1Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland.
JAMA network open
|January 29, 2025
概括
肥胖药物出现了显著的增长,其中显著的转向是塞马格卢提德和蒂尔泽帕提德. 这些药物的处方和在线搜索的增加显示出与公共利益有很强的相关性.
科学领域:
- 药理学和内分泌学 药理学和内分泌学
- 公共卫生和流行病学
- 医疗信息学 医疗信息学
背景情况:
- 肥胖是一个日益严重的全球健康问题.
- 类似葡萄糖类1受体激动剂 (GLP-1RAs) 像塞马格卢提德和蒂尔泽帕提德在体重管理方面表现有前途.
- 了解处方趋势和公众对肥胖管理药物 (OMD) 的兴趣至关重要.
研究的目的:
- 分析OMD的处方模式和在线搜索趋势.
- 为了将药物使用动态与公众参与相关联.
- 检查美国OMDs不断变化的格局.
主要方法:
- 采用了一种重复的横截面研究设计.
- 关于发行处方的数据来自IQVIA国家处方审计 (美国).
- 在线搜索数据 (谷歌趋势) 和处方数据从2017年7月到2024年2月收集.
主要成果:
- 在美国,超过6900万张OMD处方被发行.
- 观察到OMD处方的显著增加,到2024年2月每月达到150万.
- 塞马格卢提德 (Wegovy) 和提泽帕提德 (Zepbound) 显示出实质性的增长,其处方量和在线搜索趋势之间存在强烈的相关性 (分别r=0.97和r=0.90).
结论:
- 自2017年以来,OMDs的动态增长和不断变化的市场份额一直在增长.
- 在处方方面发生了显著的转变,正朝着西马格卢提德和蒂尔泽帕提德的方向发展.
- 处方和在线搜索的同时增加凸显了公众意识和药物吸收之间的实时联系.
相关概念视频
02:20Longitudinal Research
11.8K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.8K
01:12Analysis of Population Pharmacokinetic Data
220
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
220
01:19Pharmacovigilance
770
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
770
01:24Obesity
371
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
371
01:02Prescription, Nonprescription and Orphan Drugs
683
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
683
01:25Drug Regulation
1.3K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
1.3K