对环境压力和逆境的敏感性以及肺癌
Yingxi Chen1, Qing Lan1, Jing Yu2
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland.
JAMA network open
|January 29, 2025
概括
对环境压力和逆境的遗传估计敏感性与患肺癌的更高风险有关. 需要进一步的研究来了解不同人群中的这种联系.
科学领域:
- 遗传学 遗传学 是一个
- 环境健康 环境健康
- 在瘤学瘤学.
背景情况:
- 心理社会因素,包括对环境压力和逆境的敏感性,越来越多地被认为对癌症发展的潜在影响.
- 了解将压力敏感性与癌症病因学联系在一起的生物机制对于公共卫生倡议至关重要.
研究的目的:
- 调查基因估计对环境压力和逆境的敏感性与患肺癌的风险之间的关联.
- 探索不同肺癌组织学亚型和祖先群体之间这种关联的潜在变异.
主要方法:
- 使用双样本的门德尔随机化 (MR) 方法来评估因果关系.
- 采用了来自全基因组关联研究 (GWAS) 的遗传数据,以确定压力敏感性的遗传变异,以及国际肺癌联盟的大规模肺癌全基因组元分析.
- 分析了来自英国生物银行超过35万个人的数据,并对肺癌病例和对照进行了交叉祖先分析.
主要成果:
- 基因估计对环境压力和逆境的敏感性在欧洲祖先的个体 (OR, 1.49; 95% CI, 1.13-1.98) 和交叉祖先分析 (OR, 1.45; 95% CI, 1.13-1.85) 中显示出与肺癌风险增加的显著关联.
- 在欧洲祖先的状细胞癌 (OR,1.69;95% CI,1.06-2.70) 和东亚祖先的腺癌 (OR,2.04;95% CI,1.00-4.18) 中观察到显著的关联.
- 在非洲血统的个人中,没有发现肺癌组织学亚型之间的显著关联.
结论:
- 对环境压力和逆境的敏感性,当通过遗传评估时,与肺癌的风险增加有关.
- 这些发现强调了在癌症风险评估和预防策略中考虑心理社会压力的重要性.
- 需要进一步研究各种人群中压力,遗传和癌症之间的复杂相互作用.
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