临床协会和患病率的周周细胞超反射卵状质量类似的结构在头骨突
Jacqueline G Jeon-Chapman1, Tais Estrela, David Zurakowski
1Department of Ophthalmology (JGJ-C, TE, Y-HC, LRD, RAG), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; Frank H. Netter Medical School (JGJ-C), North Haven, Connecticut; and Department of Anesthesiology (DZ), Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
概括
周周膜超反射卵状质量结构 (PHOMS) 在骨突症的儿童中更为普遍,这表明视神经病变的风险更高. 这些发现与内压升高和乳头有关,有助于监测视力变化.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 儿科 儿科 儿科
背景情况:
- 骨突症对内压力升高 (ICP) 具有显著的风险,导致皮皮瘤和视力缩.
- 在这些患者中诊断视神经病变是复杂的,原因是暴露角膜病变,眼盲和认知障碍等混因素.
- 在光学连贯断层扫描 (OCT) 上,周周卵膜超反射卵性质量样结构 (PHOMS) 与 papilledema 和视神经病变有关.
研究的目的:
- 为了确定患有综合征性关突症的儿童中PHOMS的患病率.
- 调查PHOMS与该人群中视神经病变的已知风险因素之间的关联.
主要方法:
- 一项横截面回顾性研究包括2010年至2023年期间评估的60名患有综合性关节缩症患者的118只眼睛.
- 视神经OCT体积扫描被神经眼科医生审查以确定PHOMS.
- 收集的数据包括人口统计,ICP病史,乳头,奇亚里形,阻塞性睡眠呼吸暂停 (OSA) 和视力敏.
主要成果:
- 患者中PHOMS的患病率为28.3%,眼睛的患病率为22.0%,明显高于没有骨突症的儿童 (P < 0.001).
- PHOMS与先例升高的ICP (OR 14.4,P < 0.001) 和并发的乳头 (OR 40.4,P < 0.001) 有着强烈的关联.
- OSA,奇亚里形,视力敏,突变变异和球形等效都没有独立地与PHOMS相关.
结论:
- 与没有这种情况的同龄人相比,患有骨突症的儿童患PHOMS的患病率更高.
- 存在PHOMS与升高的ICP和 papilledema显著相关.
- PHOMS可以作为一种有价值的临床标志物,用于识别视神经病变,并监测头骨突症患者和其他复杂病例中的 papilledema 复发.
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