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相关概念视频

Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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相关实验视频

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Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
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在重建性儿科复杂下肢创伤中的细胞皮肤矩阵:一项观察性研究

Oluwatobi Adegboye1, Kamlen Pillay, Saleigh Adams

  • 1Author Affiliations: St Andrew's Anglia Ruskin (StAAR) Research Group, Faculty of Health, Education, Medicine, and Social Care, Anglia Ruskin University, Chelmsford, UK (Dr Adegboye); Division of Plastic and Reconstructive Surgery, Red Cross War Memorial Children's Hospital; and Division of Plastic & Reconstructive Surgery, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa (Dr Pillay and Prof Adams).

Journal of trauma nursing : the official journal of the Society of Trauma Nurses
|January 29, 2025
PubMed
概括

无细胞皮肤基因表现为儿科下肢创伤有前途,特别是在与负压伤口治疗相结合时. 这种方法可以减少儿童感染和痕等并发症.

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Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
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科学领域:

  • 再生医学是一种再生医学.
  • 儿科手术 儿科手术
  • 伤口愈合 治愈 伤口愈合

背景情况:

  • 对于成年人的下肢损伤,细胞皮肤矩阵 (ADM) 已建立.
  • 关于ADM在儿科复杂下肢创伤中使用的数据有限.

研究的目的:

  • 调查ADM在患有复杂下肢创伤的儿童中的安全性和有效性.
  • 评估ADM相关的并发症和负压伤口治疗 (NPWT) 的作用.

主要方法:

  • 在54名接受PelnacTM ADMs治疗的儿童中进行了回顾性观察队列研究.
  • 2010-2017年在南非一家三级医院收集的数据.
  • 主要结局:与ADM相关的并发症;次要结局:使用NPWT.

主要成果:

  • 在54名儿童中,有45名儿童在没有并发症的情况下康复.
  • 9名儿童出现并发症,包括急性损伤 (4),感染 (3),过度缩性痕 (5) 和关节收缩 (4).
  • 接受NPWT的患者的并发症较少,特别是急性ADM损失.

结论:

  • ADM似乎是一种安全有效的选择,用于儿科复杂的下肢创伤.
  • 同时使用NPWT与ADM可能会改善结果并减少并发症.