在重建性儿科复杂下肢创伤中的细胞皮肤矩阵:一项观察性研究
Oluwatobi Adegboye1, Kamlen Pillay, Saleigh Adams
1Author Affiliations: St Andrew's Anglia Ruskin (StAAR) Research Group, Faculty of Health, Education, Medicine, and Social Care, Anglia Ruskin University, Chelmsford, UK (Dr Adegboye); Division of Plastic and Reconstructive Surgery, Red Cross War Memorial Children's Hospital; and Division of Plastic & Reconstructive Surgery, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa (Dr Pillay and Prof Adams).
概括
无细胞皮肤基因表现为儿科下肢创伤有前途,特别是在与负压伤口治疗相结合时. 这种方法可以减少儿童感染和痕等并发症.
科学领域:
- 再生医学是一种再生医学.
- 儿科手术 儿科手术
- 伤口愈合 治愈 伤口愈合
背景情况:
- 对于成年人的下肢损伤,细胞皮肤矩阵 (ADM) 已建立.
- 关于ADM在儿科复杂下肢创伤中使用的数据有限.
研究的目的:
- 调查ADM在患有复杂下肢创伤的儿童中的安全性和有效性.
- 评估ADM相关的并发症和负压伤口治疗 (NPWT) 的作用.
主要方法:
- 在54名接受PelnacTM ADMs治疗的儿童中进行了回顾性观察队列研究.
- 2010-2017年在南非一家三级医院收集的数据.
- 主要结局:与ADM相关的并发症;次要结局:使用NPWT.
主要成果:
- 在54名儿童中,有45名儿童在没有并发症的情况下康复.
- 9名儿童出现并发症,包括急性损伤 (4),感染 (3),过度缩性痕 (5) 和关节收缩 (4).
- 接受NPWT的患者的并发症较少,特别是急性ADM损失.
结论:
- ADM似乎是一种安全有效的选择,用于儿科复杂的下肢创伤.
- 同时使用NPWT与ADM可能会改善结果并减少并发症.
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