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Updated: May 30, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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移动活性位点在IMP脱酶抑制剂结合中的作用

Xingyou Wang1, Masha M Rosenberg2, Youngchang Kim3,4

  • 1Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454, United States.

ACS infectious diseases
|January 29, 2025
PubMed
概括

氨酸5'-单酸脱酶 (IMPDH) 中的一个移动活性位点影响了抗生素抑制剂的功效. 突变显示,皮接触并不总是与有利的相互作用相关,这影响了对细菌感染的药物开发.

关键词:
在 IMPDH 里面.在STD-NMR中.抗生素 抗生素是一种抗生素.酶动力学 酶动力学抑制剂选择性的抑制剂选择性稳定状态前的动力学.

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