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Hsa_circ_0000105通过miR-541-3p/S100A11轴促进鼻癌恶性瘤的发生

LuXing Peng¹, Jian Qin¹, DeFeng Qing²

¹Department of Clinical Oncology Center, Radiotherapy Ward 3, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning City, Guangxi Zhuang Autonomous Region, China.

Clinics (Sao Paulo, Brazil)

|January 29, 2025

概括

循环RNA hsa_circ_0000105通过调节miR-541-3p/S100A11轴促进鼻癌 (NPC) 的进展. 这一发现揭示了hsa_circ_0000105作为NPC治疗的潜在治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

鼻癌 (NPC) 是一个重要的健康问题,具有复杂的生物行为.
了解NPC进展背后的分子机制对于开发有效治疗非常重要.

研究的目的:

研究hsa_circ_0000105在调节鼻癌 (NPC) 生物行为中的作用.
为了阐明涉及hsa_circ_0000105在NPC中的分子机制.

主要方法:

在NPC组织和细胞系中分析hsa_circ_0000105,miR-541-3p和S100A11的表达,使用RT-qPCR和西部抹黑.
通过CCK-8,EdU,Transwell,伤口愈合和流细胞计测试评估NPC细胞的生物行为.
使用双 luciferase 报告器和 RIP 试验调查 hsa_circ_0000105/miR-541-3p/S100A11 相互作用,并使用瘤异种移植模型在体内评估 hsa_circ_0000105.

主要成果:

在NPC中,hsa_circ_0000105和S100A11被调高,而miR-541-3p被调低.
hsa_circ_0000105直接针对miR-541-3p,影响S100A11表达并促进NPC细胞的增殖,迁移和入侵.
在体内研究证实hsa_circ_0000105促进NPC瘤生长.

结论:

hsa_circ_0000105 作为鼻癌的致癌因子.
hsa_circ_0000105/miR-541-3p/S100A11轴在促进NPC恶性瘤方面发挥着至关重要的作用.
hsa_circ_0000105代表了NPC的潜在治疗目标.

关键词:

皮质 - 介质细胞过渡.微RNAs是一种微RNA.鼻瘤是指鼻的新生体.RNA,圆形的RNA,圆形的RNA.S100A11 蛋白质是一种蛋白质.

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