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青春期异常性关节炎中的代谢组:在接受甲醇治疗的患者中具有明显的特征

Renato B Tomioka^1,2, Gabriela R V Ferreira³, Nadia E Aikawa^1,3

¹Division of Rheumatology, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil

Clinics (Sao Paulo, Brazil)

|January 29, 2025

概括

接受美托雷克萨特 (MTX) 治疗的青春性异常性关节炎 (JIA) 患者表现出明显的血清代谢概况. 在JIA患者中,MTX使用似乎与增强的线粒体功能有关.

科学领域:

生物化学生化学
代谢学代谢学代谢学
免疫学免疫学免疫学

背景情况:

青少年异常性关节炎 (JIA) 是一种复杂的自身免疫性疾病,影响儿童.
了解JIA中的生化变化对于开发向疗法至关重要.
甲基 (MTX) 是一种常见的治疗JIA,但其精确的代谢作用需要进一步阐明.

研究的目的:

为了研究来自JIA患者和健康对照的血清中的定量生物化学代谢物差异.
为了确定与JIA和MTX治疗相关的代谢途径修改.
在JIA中评估MTX对线粒体代谢和肠道吸收功能的影响.

主要方法:

横截面研究设计涉及33名JIA患者 (21名没有MTX,12名有MTX) 和28名健康对照.
向电喷离子合质谱仪用于血清代谢分析.
生物化学代谢物的定量评估,包括自由卡尼丁和卡尼丁.

主要成果:

与对照组相比,接受MTX治疗的JIA患者表现出明显增加的自由肉丁度.
自由卡尼丁的增加表明,在使用MTX时,线粒体代谢和肠道吸收功能得到了增强.
相反,多关节性和全身性JIA亚型显示线粒体新陈代谢下降,由降低的乙卡尼丁水平表明.

结论:

在接受MTX治疗的JIA患者中发现了明显的血清代谢特征.
在JIA患者中,MTX治疗似乎与改善线粒体功能有关.
代谢分析提供了关于JIA及其治疗的系统性影响的宝贵见解.

关键词:

生物标志物生物标志物青少年无形性关节炎 (Juvenile idiopathic arthritis) 是一种不良的疾病.青少年异常性关节炎亚型青少年异常性关节炎亚型代谢学代谢学代谢学甲索特雷克萨特 (甲索特雷克萨特) 甲索特雷克萨特

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