内分泌干扰化学物质和女性生殖衰老
Jiaxin Wu1, Siobán D Harlow1, John F Randolph1,2
1Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan.
Seminars in reproductive medicine
|January 29, 2025
概括
重金属和PFAS等某些化学物质会影响女性的生殖老化,影响卵巢储备和更年期的时间. 需要进一步的研究来了解这些内分泌干扰的化学效应,并为公共卫生战略提供信息.
科学领域:
- 环境健康 环境健康
- 生殖内分泌学 生殖内分泌学
- 毒理学 毒理学 毒理学
背景情况:
- 女性的生殖衰老影响健康,受到荷尔蒙变化和更年期开始的影响.
- 内分泌干扰化学物质 (EDC) 是影响生殖衰老的潜在可改变因素.
- 了解EDC的影响对于公共卫生和解决健康差异至关重要.
研究的目的:
- 审查体内,体外和流行病学数据重金属和PFAS在女性生殖老化.
- 综合当前关于EDC对卵巢功能和更年期的影响的知识.
- 为了确定未来干预的研究差距.
主要方法:
- 文献综述合成体内,体外和流行病学研究.
- 专注于内分泌干扰化学物质:重金属和 perfluoroalkyl 和 polyfluoroalkyl 物质 (PFAS).
- 对卵巢形态,卵泡生成,类固醇生成,卵巢储备和更年期年龄的影响分析.
主要成果:
- 重金属在体外和体内改变卵巢形态,卵泡生成和类固醇生成.
- 流行病学研究将重金属与卵巢储备减少和更早更年期联系起来.
- PFAS证据有限且不一致;与更早更年期和雌激素降低相关,但没有卵巢储备.
结论:
- 重金属显著影响女性生殖衰老标志物.
- 需要对EDC影响进行更全面的流行病学研究,包括卵巢储备和更年期.
- 调查结果可以为减少危险暴露和改善妇女健康的干预措施提供信息.
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