使用一种新的液体人乳强化剂在非常低出生体重婴儿中改善生长速度:一个多中心的回顾性研究
Fernando Moya1, Jennifer Fowler2, Adrian Florens3
1Betty Cameron Children's Hospital and University of North Carolina Medical School, Wilmington, North Carolina.
American journal of perinatology
|January 29, 2025
概括
一种新的液体母乳强化剂 (LHMF-NEW) 与母乳强化剂-酸性液体 (HMF-AL) 相比,在出生时体重非常低的婴儿 (VLBW) 中显示出更快的生长速度. 此外,LHMF-NEW还显示了代谢酸性的发病率降低,食耐受性和其他结果相似.
科学领域:
- 新生儿营养与生长新生儿营养与生长
- 儿科胃肠病学 儿科胃肠病学
- 临床儿科 临床儿科
背景情况:
- 在非常低出生体重 (VLBW) 婴儿中优化生长和耐受性对于长期健康结果至关重要.
- 人母乳强化是VLBW婴儿的标准做法,但不同的强化剂配方可能会影响生长和耐受性.
- 开发了一种新型的液体母乳强化剂 (LHMF-NEW),以潜在地改善现有的酸性液体配方 (HMF-AL).
研究的目的:
- 为了比较接受LHMF-NEW与HMF-AL的VLBW婴儿的生长速度和食耐受性.
- 评估二次结局,包括晚发性败血症,死性肠球炎和代谢性酸性疾病的发生率.
主要方法:
- 一项回顾性多中心研究,涉及3个新生儿重症监护病房的515名VLBW婴儿.
- 强化期间的生长速度 (g/kg/d) 是主要结果,使用重复测量回归分析.
- 用适当的统计测试评估了食耐受性,晚发性败血症,死性肠球炎和代谢性酸作为二次结果.
主要成果:
- 接受LHMF-NEW的婴儿与接受HMF-AL的婴儿相比,表现出明显更高的生长速度 (p=0.001),尽管他们摄入了类似的液体,卡路里和蛋白质.
- 两个强化剂组之间的食不耐受率是可比的.
- 在LHMF-NEW组中,代谢酸性的发生率较低,而晚发性败血症和死性肠球炎的发生率没有显著差异.
结论:
- 与HMF-AL.相比,LHMF-NEW在强化期间在VLBW婴儿中促进了更快的体重增加速度.
- LHMF-NEW与降低代谢性酸性疾病的风险有关,而不会影响养耐受性,败血症或死性肠球炎的发生率.
- 这些发现表明,LHMF-NEW是一种安全有效的选择,可以改善VLBW婴儿的生长结果.
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