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智能自转换纳米系统可以克服生物障碍,提高瘤治疗效率

Jun Tao¹, Weiqing Ning¹, Wei Lu¹

¹State Key Laboratory of Organic Electronics and Information Displays, Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, PR China.

Journal of controlled release : official journal of the Controlled Release Society

|January 29, 2025

概括

智能自变纳米系统 (SSTNs) 可以改变特性,克服生物障碍,改善癌症治疗. 本综述探讨了SSTN设计和在药物输送中的应用,以提高疗效和诊断.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
药物运输药物运输药物运输

背景情况:

传统的纳米医学面临着克服生物障碍的挑战,因为它具有固定的特性.
运输效率低下导致药物输送不足,癌症治疗效率降低.
智能自我转换纳米系统 (SSTNs) 通过在生物体内调整特性提供了一个解决方案.

研究的目的:

审查五种流行的SSTN类型的设计策略.
探索SSTNs在提高药物输送中的生物医学应用.
讨论SSTNs在癌症治疗和诊断中的未来机会和挑战.

主要方法:

总结尺寸,电荷,水性,刚性和形态自变纳米系统的设计原则.
分析有关这些SSTN体内应用的文献.
讨论当前的局限性和未来的前景.

主要成果:

SSTN可以动态地改变物理化学特性,如尺寸,电荷和刚性.
这些转变有助于改善循环时间,组织透和细胞吸收.
SSTNs显示出提高癌症治疗疗效的显著潜力.

结论:

在传统的纳米医学上,SSTNs是一个有希望的进步.
它们的适应性是克服生物障碍以向药物输送的关键.
需要进一步的研究来应对癌症治疗和诊断中的临床翻译的挑战.

关键词:

增强细胞内部化的作用.增强瘤的透率提高瘤的透率增强瘤治疗的作用延长了循环时间.智能自我转型的智能自我转型

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