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Updated: May 30, 2025

Subcellular Fractionation of Primary Chronic Lymphocytic Leukemia Cells to Monitor Nuclear/Cytoplasmic Protein Trafficking
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一个新的FOXM1-BCL2A1轴决定了AML中对venetoclax的不利反应

Sanjeev Raghuwanshi1, Ahmed Magdy2, Nissim Hay2

  • 1University of Illinois at Chicago, Department of Medicine, Chicago, Illinois, USA.

The Journal of biological chemistry
|January 29, 2025
PubMed
概括

在急性髓性白血病 (AML) 中,蛋白质FOXM1 (叉头盒M1) 通过增加BCL2A1.1.来驱动对venetoclax的耐药性. 抑制这个FOXM1-BCL2A1轴使AML细胞对venetoclax治疗敏感.

关键词:
在AML,AML就是AML.在BCL2A1A1中.在FOXM1中,我们可以看到FOXM1.灭症 (apoptosis) 是一种死亡的过程.维尼托克拉克斯 (Venetoclax) 是一个

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