相关实验视频

Updated: May 30, 2025

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders

Published on: October 4, 2022

研究气溶喷气打印用于制备固体剂型的研究

Alice J Turner¹, Elke Prasad², Alastair J Florence¹

¹EPSRC CMAC Future Manufacturing Research Hub, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 99 George Street, Glasgow G1 1RD UK.

International journal of pharmaceutics

|January 29, 2025

概括

气溶喷气打印增强了难溶化合物的药物溶解. 这种可扩展的技术可以创建无形的药物配方,溶解率高达10倍,提供灵活的剂型设计.

科学领域:

制药技术制药技术制药技术
材料科学材料科学材料科学
药物输送系统药物输送系统

背景情况:

口服药物输送是首选的,但由于许多活性药物成分 (API) 的溶解性较差而受到限制.
生物制药分类系统 (BCS) 的II类药物通常具有较差的溶解性,阻碍了口服.
现有的可溶性增强方法缺乏适合量身定制剂型的可扩展性和灵活性.

研究的目的:

研究气溶喷气打印作为一种可扩展和灵活的方法,用于改善BCSII类药物的溶解.
探索聚合物辅助剂含量对气溶喷气打印药物的形态和溶解特性的影响.
评估气溶喷气打印在创建具有增强溶解的无形药物配方方面的潜力.

主要方法:

气溶喷气打印被用来制造药物配方,含有不同度的聚合物辅助剂.
分析了印刷药物配方的形态特征.
测量药物溶解率,并与物理混合物进行比较.

主要成果:

气溶喷气打印允许精确控制药物分发,缩放和分层.
纯活性药物成分 (API) 导致晶体材料;增加聚合物含量诱导形态变化.
75% (重量/重量溶液) 聚合物或更高的配方产生了一个完全无形的产品.
与物理混合物相比,无形产品的药物溶解率增加了10倍.

结论:

气溶喷气打印是一种新,有效和可扩展的技术,用于增强药物溶解.
该方法具有高空间精度,可灵活定制剂型.
通过气溶喷气打印生成无形药物配方,显著改善溶解特性.

关键词:

增材制造增材制造是一种增材制造.气溶喷气打印是一种喷气式打印.没有形态的无形.个性化药物是个性化的药物.可扩展性可扩展性固体的分散固体的分散可溶性溶解度可溶性溶解度

更多相关视频

A System to Create Stable Nanoparticle Aerosols from Nanopowders

A System to Create Stable Nanoparticle Aerosols from Nanopowders

Published on: July 26, 2016

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

相关概念视频

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...