基于多孔微针的离体驱动的透皮药物递送系统,用于治疗高尿血症
Rui Wang1, Han Wang2, Rui Yao1
1School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China; International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers, Hangzhou 310018, China.
International journal of pharmaceutics
|January 29, 2025
概括
一种新的多孔微针系统通过通过皮肤活跃输送Allopurinol来增强高尿血症治疗. 这种以离子泳驱动的微针方法为管理高尿酸水平提供了用户友好的,持久的治疗效果.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 高尿路血症的管理需要有效和持续的药物输送.
- 目前的治疗方法可能缺乏用户友好性或长期有效性.
- 通过皮肤递送药物提供了一个潜在的替代方案,以改善患者的遵守.
研究的目的:
- 开发和评估一种以离子泳驱动的多孔微针 (IPMN) 系统,用于治疗高尿血症.
- 使用IPMN系统评估Allopurinol (AP) 通过皮肤传递的效率和抗高尿血效应.
- 调查自我管理和长期治疗效果的潜力.
主要方法:
- 使用生物相容材料,高孔度和物质交换能力制造多孔微针 (PMN).
- 在体外评估AP通过皮肤传递的控制通过电离体泳电流.
- 在小鼠模型中,对IPMN系统在降低血清尿酸 (SUA) 水平方面的有效性进行了体内评估.
主要成果:
- 通过IPMN系统,AP的通过皮肤传递得到了控制,而离子体外注增加了药物释放.
- 在体外,1.54毫克的AP在1.5V下在30分钟内释放.
- 在体内研究显示,在2小时内,SUA水平显著降低 (至~158.2μmol/L),持续7小时,表明长期治疗效果.
结论:
- 离子泳驱动的多孔微针系统是有效的通过皮肤输送Allopurinol.
- 这种系统提供了持续的抗高尿路血症效应,显示了长期管理的潜力.
- 该IPMN系统提供了一个低成本,用户友好的方法,用于hyperuricemia的自我管理.
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