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同时存在的自主皮质醇分泌在初级阿尔多斯特主义
Tugba Barlas1, Alev Eroglu Altinova1, Fusun Balos Toruner1
1Gazi University, Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey.
Annales d'endocrinologie
|January 29, 2025
概括
大约26%的原发性阿尔多斯特隆症 (PA) 患者也有自主皮质醇分泌 (ACS). 虽然没有ACS的PA患者表现出更高的阿尔多水平,但同时存在的ACS并没有显著恶化临床结果.
科学领域:
- 内分泌学 在内分泌学.
- 内部医学 内部医学
- 心脏病学 心脏病学
背景情况:
- 主要的阿尔多斯特 (PA) 和自主皮质醇分泌 (ACS) 越来越多地被认为是共存的内分泌疾病.
- 了解PA患者同时存在的ACS的发生率和影响对于临床管理至关重要.
研究的目的:
- 在被诊断为原发性阿尔多斯特主义 (PA) 的患者中确定自主皮质醇分泌 (ACS) 的发生率.
- 评估同时存在的ACS对PA患者临床和实验室参数的影响.
主要方法:
- 对92名PA患者的人口统计数据,并发病症和实验室/成像结果的回顾性分析.
- 根据一夜间1毫克德克萨米他抑制试验结果 (>1.8μg/dL对于ACS的PA) 将患者分类为有ACS的PA或没有ACS的PA组.
主要成果:
- 二十四名患者 (26.1%) 被诊断出患有PA和同时存在的ACS.
- 在PA与ACS组中,平均年龄,体重指数,女性患者比例和最大腺瘤直径都较高.
- 没有ACS的患者在基础和注后的血中阿尔多素度 (PAC) 显着更高.
- 两组之间没有观察到抗高血压治疗,糖尿病,冠状动脉疾病,蛋白尿或膜过率的显著差异.
- 左心室缩 (LVH) 在49.4%的患者中存在,PAC和性别是相关因素.
结论:
- 皮质醇共分泌 (ACS) 在大约四分之一的PA患者中发生.
- 与同时存在ACS.患者相比,没有ACS的PA患者表现出更高的PAC.
- 在PA患者中同时存在的ACS似乎没有显著的负面影响该队列中的临床参数.
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