超加工食品摄入量与代谢功能障碍相关的脂肪性肝病之间的横断关联
Natalie Sun1, Brenton Prescott2, Jiantao Ma3
1Department of Internal Medicine, Boston Medical Center, USA.
Clinical nutrition ESPEN
|January 29, 2025
概括
超加工食品 (UPF) 的消费与患肝硬化症 (肝脏疾病) 的几率增加有关. 需要进一步的研究来确定减少UPF摄入量是否可以降低肝纤维化风险.
科学领域:
- 营养科学 营养科学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 的患病率在全球范围内正在上升.
- 超加工食品 (UPF) 的消费量也大幅增加.
- 在UPF摄入量和MASLD之间的关联仍然不清楚.
研究的目的:
- 调查UPF消费与肝硬化和纤维化存在的关系.
- 检查UPF摄入量和肝脏健康标志物之间的剂量反应关系.
主要方法:
- 对2458名成年人进行横截面研究,使用振动控制的短暂弹性体和食物频率问卷.
- 用NOVA系统对食品加工水平进行分类的饮食摄入量.
- 多变量逻辑回归模型评估了UPF摄入量与肝硬化症 (CAP ≥290 dB/m) 和纤维化 (LSM ≥8.2 kPa) 之间的关联,并调整了混因素.
主要成果:
- 较高的UPF摄入量与肝硬化症的几率增加显著相关 (或每SD增加1.33).
- 在UPF消费和肝硬化症之间观察到明确的剂量反应关系.
- 在UPF摄入量和肝纤维化之间没有发现显著的关联;BMI调整减弱了UPF与肝脏的关联.
结论:
- UPF的消费与肝脏肥胖症有积极的联系.
- 需要进一步的纵向研究来确认减少UPF摄入量是否可以减轻肝纤维化风险.
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