甲状腺素可以缓解由联合放射治疗和免疫治疗引起的间歇性肺病
You Mo1, Yiwei Qin2, Pengwei Li3
1Laboratory of Molecular Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China; Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Cancer letters
|January 29, 2025
概括
免疫检查点封锁和放射治疗增加了肺损伤的风险. 编程死亡配体-1 (PD-L1) 和甲状腺素是治疗辐射诱导的间歇性肺病 (ILD) 的关键标.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点阻塞 (ICB) 与放射治疗 (RT) 结合,改善了患者的生存率,但增加了肺部不良事件 (AE).
- 在接受ICB加RT的患者中,间歇性肺病 (ILD) 是一个重大问题.
- 识别ILD的新药标是至关重要的.
研究的目的:
- 调查ICB和RT在引起肺部AE的相互作用.
- 为了确定ILD的潜在药物点.
- 探索编程死亡连接体-1 (PD-L1) 在ILD中的作用.
主要方法:
- 不成比例分析和COX回归被用来分析肺部AE的ICB和RT相互作用.
- 全基因组关联研究,转录组分析和体内模型确定了PD-L1的作用.
- 门德尔的随机化分析确定了药物标,用于验证的是非小细胞肺癌 (NSCLC) 患者的临床数据.
主要成果:
- 与RT结合的ICB显示肺部AE的风险最高 (报告几率比率=3.727).
- 抗PD-L1治疗比抗PD-1或抗细胞毒性淋巴细胞抗原-4 (CTLA-4) 增加了肺部AE的风险.
- 甲状腺激素受体被确定为药物点,甲状腺素对肺纤维化表现出抑制作用.
结论:
- 在ICB和RT诱导的ILD中,PD-L1起着重要作用.
- 甲状腺素显示出作为肺纤维化治疗剂的潜力.
- 甲状腺功能在临床上是管理ILD的关键.
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