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慢性Cr(VI) 暴露引起的生物毒性涉及Phoxinus lagowskii Dybowski的肝脏微生物群-肠轴干扰,基于多omics技术
Xinchi Shang1, Xinghua Che2, Kai Ma2
1Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin, 150070, China; College of Life Science, Northeast Agricultural University, Harbin, 150036, China.
Environmental pollution (Barking, Essex : 1987)
|January 29, 2025
概括
六价 (Cr(VI)) 暴露会损害鱼肝和肠道微生物,破坏肠肝轴. 这项研究揭示了Cr(VI) 导致组织损伤,肠道失调和代谢障碍,影响鱼类的健康.
科学领域:
- 环境毒理学环境毒理学
- 鱼类生物学 鱼类生物学
- 微生物组研究 微生物组研究
背景情况:
- 六价 (Cr(VI)) 是一种有毒的工业污染物,对环境产生重大影响.
- 长期暴露于Cr6可以导致代谢障碍和组织损伤,但其对鱼肝和肠道微生物的影响还未得到充分研究.
- 肠肝轴在保持鱼的健康和恒温中起着至关重要的作用.
研究的目的:
- 阐明Cr(VI) 影响普通鱼肠肝轴的机制.
- 研究Cr(VI) 暴露对鱼类肝脏和肠道微生物群落的影响.
- 了解肠道失调,肝脏代谢和Cr (VI) 毒性之间的关系.
主要方法:
- 多原子分析 (代谢学,微生物组测序)
- 血清学检测试验 血清学检测试验
- 组织形态学检查 组织形态学检查
- 测量生理和生化指数测量
- 常见鱼暴露于对照剂,低剂量 (0.5 mg/L) 和高剂量 (2 mg/L) Cr (VI).
主要成果:
- 暴露于Cr (VI) 会导致严重的肝细胞损伤,肠缩和Cr (VI) 在剂量依赖的方式在组织中积累.
- 肠道微生物分析显示,有益细菌 (如Akkermansia) 的减少和有害细菌 (如Escherichia/Shigella) 的增加,这表明存在失能.
- 由于肠道损伤而增加的血脂多糖 (LPS) 水平加剧了肝脏代谢障碍,改变了关键代谢物并诱导了肝毒性.
结论:
- 慢性Cr(VI) 压力会破坏肠道微生物的平衡,并损害鱼肝中的脂肪酸和氨基酸代谢.
- 从肠道转移到肝脏的LPS扩大了Cr(VI) 诱导的肝毒性,突出了肝脏-微生物群-肠道轴作为一个关键的目标.
- 这项研究为鱼类肠肝系统中Cr (VI) 的毒理机制提供了新的见解,这对于环境风险评估至关重要.
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