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Updated: May 30, 2025

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
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通过使用多切片替代模型扫描传输电子显微镜来改善纳米粒子尺寸估计.

Henrik Eliasson1, Rolf Erni1,2

  • 1Electron Microscopy Center, Empa - Swiss Federal Laboratories for Materials Science and Technology, Überlandstrasse 129, 8600 Dübendorf, Switzerland.

Nano letters
|January 29, 2025
PubMed
概括

我们开发了一种更快的方法来模拟扫描传输电子显微镜 (STEM) 图像,使机器学习能够创建大型数据集. 这大大提高了纳米粒子大小估计的准确性.

关键词:
标志性描述 标志性描述不同质的催化剂.机器学习 机器学习纳米颗粒 纳米颗粒扫描传输电子显微镜扫描传输电子显微镜综合数据 综合数据

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Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
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A scanning electron microscope (SEM) is used to study the surface features of a sample by using an electron beam that scans the sample surface in a two-dimensional manner. Typically, areas between ~1 centimeter to 5 micrometers in width can be imaged. SEM can be used to image bacteria, viruses, tissues as well as larger samples like insects. Conventional SEM gives a magnification ranging from 20X to 30,000X and spatial resolution of 50 to 100 nanometers.
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