最小的甲基马暴露引起的致命性泛细胞衰竭
Xiu Ying Au1, Patricia L Kapsner1, Nancy Shrestha1
1Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
BMJ case reports
|January 29, 2025
概括
甲基马可以导致致命的胰岛素缩小症,即使在低剂量和短时间暴露. 标准治疗可能会失败,需要骨髓移植,并强调患者教育早期症状识别.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲基马是一种常见的甲状腺功能障碍的治疗方法.
- 胺胺,包括甲基马,携带血液学副作用的风险.
- 目前的指导方针不要求在胺胺治疗时进行常规的全血细胞计监测.
研究的目的:
- 要突出与甲基马相关的耐火性泛细胞衰竭致命病例.
- 要强调,在低累积剂量和短时间的暴露时间下,胰岛素减肥会发生.
- 为了强调标准治疗的潜在无效性和骨髓移植的必要性.
主要方法:
- 案例报告的呈现方式.
- 审查患者的治疗史和不良事件.
- 讨论临床影响和管理策略.
主要成果:
- 在接受甲基马治疗的患者中出现了耐火性泛细胞衰竭.
- 尽管累积剂量低,治疗时间短,但这种情况仍然发生.
- 标准的医疗干预措施是无效的,导致了致命的结果.
- 骨髓移植被认为是一种潜在的,尽管最终没有成功的干预.
结论:
- 甲基马诱导的胰岛素衰竭可以是严重的,迅速发作,并可能致命的,无论剂量或持续时间.
- 医生必须警患者感染和血液学异常的迹象.
- 在开始甲基马治疗之前,提高患者对泛细胞衰竭早期预警症状的教育至关重要.
更多相关视频
08:13Rapid Quantification of Mitogen-induced Blastogenesis in T Lymphocytes for Identifying Immunomodulatory Drugs
Published on: December 27, 2016
18.7K
11:53An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C
Published on: June 1, 2018
6.6K
相关概念视频
02:23Abnormal Proliferation
4.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K