-1-T

Evelina Martinenaite1,2, Inés Lecoq1,2, Mia Aaboe-Jørgensen1

  • 1National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Herlev Hospital, Herlev, Denmark.

概括

特定于阿基纳-1的T细胞可以重新编程与瘤相关的巨细胞 (TAMs),以减少免疫抑制. 这种重编程促进了促炎性瘤微环境 (TME),为癌症免疫治疗提供了新的策略.

相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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