诺托金化物R1的药理动力学和生物活性:系统性综述
Chao Wen1, Xiaofei Liao2, Xinyun Ye3
1School of Nursing, Gannan Medical University, Ganzhou 341000, P. R. China.
The American journal of Chinese medicine
|January 29, 2025
概括
来自Panax notoginseng根的notoginsenoside R1 (NG-R1) 通过调节关键通路显示出抗炎和抗氧化作用. 提高其生物可用性可以释放其治疗各种疾病的潜力.
科学领域:
- 药理学和传统医学的医学.
- 自然产品化学 自然产品化学
- 药物开发 药物开发
背景情况:
- 帕纳克斯诺托金森根 (Panax notoginseng,简称PN) 是一种传统药物和补充剂,以维持微循环平衡而闻名.
- 诺托金化物R1 (NG-R1),是PN根的关键化合物,表现出各种各样的药理活性,如抗炎,抗氧化和抗癌作用.
- 缺乏对NG-R1的药理动力学和详细的药理作用的系统阐明.
研究的目的:
- 审查诺托金森化物R1 (NG-R1) 的药物动力学特性.
- 总结NG-R1.1的药理作用和作用机制.
- 探索NG-R1.1.的结构-活性关系和潜在的治疗应用.
主要方法:
- 对Notoginsenoside R1 (NG-R1) 现有研究的文献综述.
- 对NG-R1的药理动力学概况 (包括生物可用性) 的数据分析.
- 检查NG-R1对分子点和信号通路的影响的研究.
主要成果:
- NG-R1 抑制瘤亡因子α (TNF-α) 和增强核因子红色素2相关因子2 (NRF2) 和血管内皮生长因子受体 (VEGFR) 的表达.
- 药理效应与MAPK/NF-κB,NRF2/ARE,Wnt/β-catenin和PI3K/AKT信号通路的调节有关.
- NG-R1显示出对心血管,神经,,肺,骨和糖尿病相关疾病的潜在保护作用.
结论:
- 诺托金化物R1 (NG-R1) 具有通过多个信号通路调解的显著药理活性.
- 它的治疗潜力涵盖了广泛的疾病,但临床应用受到生物可用性差的阻碍.
- 提高NG-R1的药理动力学的策略对于其作为治疗剂的发展至关重要.
关键词:
抗炎药物 抗炎药物 抗炎药物抗氧化剂是一种抗氧化剂.心血管疾病 心血管疾病神经系统疾病 神经系统疾病诺托基因化物R1 是一种诺托基因化物帕纳克斯诺托金森,药理动力学药理学 药理学是指药理学的学科.更多相关视频
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