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一个开源的3D打印平台,用于测试动物的头部固定认知灵活性.

Mark H Cristino1, Alexander C Mitchell2, Maya Preibisz-Kamat2

  • 1Department of Biomedical Engineering, University of Connecticut, Glenbrook, Storrs, Connecticut 06269.

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概括

研究人员开发了FlexRig,这是一个开源平台,用于研究小鼠的认知灵活性和决策. 这个工具有助于理解与精神疾病相关的神经回路.

关键词:
行为平台 行为平台认知灵活性 认知灵活性多感应集成的多感应集成这是一个开源的开源软件.

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科学领域:

  • 神经科学是一个神经科学.
  • 行为科学 行为科学
  • 认知科学 认知科学

背景情况:

  • 了解复杂决策的神经基础,特别是认知灵活性,对于精神疾病研究至关重要.
  • 现有的行为范式可能无法完全捕捉决策中的多式联感感官集成的细微差别.

研究的目的:

  • 介绍FlexRig,一个开源的模块化行为平台,用于研究头部固定小鼠的认知灵活性.
  • 为研究涉及多式传感线索的决策过程提供多功能工具.

主要方法:

  • 开发FlexRig,一种用于行为神经科学的集成硬件和软件平台.
  • 使用嗅觉,体感和听觉线索执行任务,将作为行为读数.
  • 建立一个头部固定注意力设置转移任务.

主要成果:

  • FlexRig提供了一个可定制,可扩展和便携的解决方案,用于各种行为分析.
  • 该平台成功地促进了对头部固定小鼠注意力设置转移的建模.
  • 证明了FlexRig用于调查认知过程及其神经基质的实用性.

结论:

  • FlexRig提供了一种新且可适应的工具,用于推进关于决策和认知灵活性的神经科学研究.
  • 该平台在翻译神经科学中具有广泛的应用,特别是用于研究精神疾病.
  • 增强研究复杂认知功能的神经支柱的能力.