Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

860
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
860
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

604
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
604
Microscopic Anatomy of Skeletal Muscles01:13

Microscopic Anatomy of Skeletal Muscles

12.9K
Skeletal muscle cells, also called muscle fibers, are distinctly elongated, multi-nucleated, slender biological units. They are packed with specialized structures designed to facilitate their primary function, which is contraction.
The muscle sarcolemma is a plasma membrane enclosing each muscle cell that conducts electrical signals called action potentials. The sarcolemma extends into the cell to form T-tubules, ensuring the neural impulses are uniformly distributed across the entire muscle...
12.9K
The Sarcomere01:08

The Sarcomere

7.5K
A sarcomere is a microscopic segment repeating in a myofibril. The sarcomere fundamentally consists of two main myofilaments: thick filaments called myosin and thin filaments called actin. These filaments interact by sliding past each other in response to stimulus. In addition to myosin and actin, several other proteins, such as tropomyosin, troponin, titin, nebulin, myomesin, α-actinin, and dystrophin, play crucial roles in regulating, structuring, and functioning of the sarcomere.
Each...
7.5K
Actin and Myosin in Muscle Contraction01:16

Actin and Myosin in Muscle Contraction

8.7K
Actin and myosin are contractile proteins that form the sarcomere found in skeletal muscle tissues for regulating muscle contraction. Actin, a globular contractile protein, interacts with myosin for muscle contraction. The skeletal tissue appears striped or striated under a microscope due to the repeated arrangement of contractile proteins actin and myosin along the length of myofibrils. Dark A bands and light I bands repeat along myofibrils, and the alignment of myofibrils in the cell causes...
8.7K
Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

4.8K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
4.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Thoroughbred horses susceptible to Recurrent Exertional Rhabdomyolysis have elevated skeletal muscle mitochondrial capacities.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Aberrant skeletal muscle morphogenesis and myofiber differentiation characterize equine myotonic dystrophy.

PloS one·2026
Same author

Identification of Antibodies to Chondrocyte and Synoviocyte Antigens in Equine Osteoarthritis.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2025
Same author

Innate immune pathway activated mesenchymal stromal cells improve function and histologic outcomes in a rodent osteoarthritis model.

Frontiers in bioengineering and biotechnology·2025
Same author

Nonexertional Rhabdomyolysis.

The Veterinary clinics of North America. Equine practice·2025
Same author

Polysaccharide Storage Myopathy.

The Veterinary clinics of North America. Equine practice·2025
Same journal

Pharmaceutical and Nutraceutical Therapies for Liver Disease.

The Veterinary clinics of North America. Equine practice·2026
Same journal

Clinical Signs of Liver Disease in Horses.

The Veterinary clinics of North America. Equine practice·2026
Same journal

Syndrome of High Gamma-Glutamyl Transferase in Racehorses.

The Veterinary clinics of North America. Equine practice·2026
Same journal

Equine Hepatology in Practice: Insights, Challenges, and Progress.

The Veterinary clinics of North America. Equine practice·2026
Same journal

Pathophysiology and Treatment of Hepatic Encephalopathy.

The Veterinary clinics of North America. Equine practice·2026
Same journal

Viral Hepatitis.

The Veterinary clinics of North America. Equine practice·2026
查看所有相关文章

相关实验视频

Updated: May 30, 2025

Immunolabelling Myofiber Degeneration in Muscle Biopsies
06:37

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Published on: December 5, 2019

8.7K

肌纤维状肌肉病变 肌纤维状肌肉病变

Stephanie J Valberg1, Zoë J Williams2

  • 1Michigan State University, Large Animal Clinical Sciences, College of Veterinary Medicine, East Lansing, MI, USA.

The Veterinary clinics of North America. Equine practice
|January 29, 2025
PubMed
概括
此摘要是机器生成的。

马中的肌纤维肌病 (MFM) 在耐力阿拉伯人与热血动物中呈现不同. 这两种形式都显示抗氧化剂减少,但温血动物表现出不适应的训练反应.

关键词:
德斯明·德斯明 (Desmin Desmin) 是一个马类动物 马类动物肌纤维细胞的情况肌肉病症 肌肉病症是指肌肉病症.聚糖的储存方式是多糖.骨架肌肉是一个骨肌肉.

更多相关视频

Isolating Myofibrils from Skeletal Muscle Biopsies and Determining Contractile Function with a Nano-Newton Resolution Force Transducer
07:55

Isolating Myofibrils from Skeletal Muscle Biopsies and Determining Contractile Function with a Nano-Newton Resolution Force Transducer

Published on: May 7, 2020

7.0K
Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
09:39

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

Published on: July 29, 2016

15.3K

相关实验视频

Last Updated: May 30, 2025

Immunolabelling Myofiber Degeneration in Muscle Biopsies
06:37

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Published on: December 5, 2019

8.7K
Isolating Myofibrils from Skeletal Muscle Biopsies and Determining Contractile Function with a Nano-Newton Resolution Force Transducer
07:55

Isolating Myofibrils from Skeletal Muscle Biopsies and Determining Contractile Function with a Nano-Newton Resolution Force Transducer

Published on: May 7, 2020

7.0K
Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
09:39

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

Published on: July 29, 2016

15.3K

科学领域:

  • 马匹神经系统学
  • 兽医内科 兽医内科
  • 分子生物学分子生物学

背景情况:

  • 肌纤维细胞肌病 (MFM) 是一种独特的肌肉疾病,其特点是肌纤维细胞的混乱和desmin积累.
  • 以前被错误地归类为糖原储存疾病,MFM现在被认为是主要肌肉病变.
  • MFM影响马匹,在不同品种中具有明显的临床表现.

研究的目的:

  • 区分耐久性阿拉伯犬 (MFM-ER) 和热血动物 (MFM-WB) 中MFM的临床和分子特征.
  • 调查氧化应激和训练反应在马MFM中的作用.
  • 为马匹提供MFM病理生理学的全面理解.

主要方法:

  • 对被诊断患有MFM的耐力阿拉伯犬和热血犬的临床案例评估.
  • 血清肌肉酶和肌球蛋白的生物化学分析.
  • 分子分析以识别训练反应特征和抗氧化剂状态.

主要成果:

  • 患有MFM (MFM-ER) 的耐力阿拉伯人通常表现为运动性拉布多米解,肌肉酶升高和肌球蛋白尿.
  • 患有MFM (MFM-WB) 的热血患者表现出与疼痛相关的行为,如运动不耐受和,血清肌肉酶正常.
  • 无论是MFM-ER还是MFM-WB,都显示了基于氨酸的抗氧化剂的减少;MFM-WB还显示了适应不良训练的分子迹象.

结论:

  • 在耐久性阿拉伯人和热血动物中,MFM呈现出明显的临床表型.
  • 减少基于氨酸的抗氧化剂是马中MFM的常见特征.
  • MFM-WB与不适应的训练反应有关,这表明多因素的病因.