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两种素浴方法的前性,交叉,比较研究

Richard Jordan Hankins¹, Luke Handke², Paul D Fey²

¹Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, USA.

Infection control and hospital epidemiology

|January 29, 2025

概括

每天洗的重症监护室 (ICU) 患者用素酸盐 (CHG) 布显著减少了皮肤微生物的殖民. 2%的CHG布表现出比4%的CHG溶液更高的疗效.

科学领域:

在重症监护室 (ICU) 进行感染控制.
赫西丁葡萄糖酸盐 (CHG) 的抗微生物有效性
医疗相关感染 (HAI) 预防策略

背景情况:

重症监护室 (ICU) 患者的赫西丁葡萄酸盐 (CHG) 洗已被确立为减少与医疗相关的感染 (HAI).
在ICU中浴CHG的最佳方法尚未最终确定.
这项研究解决了关于CHG浴协议的基于证据的指导方针的需求.

研究的目的:

为了比较2%的CHG浸布和4%的CHG溶液在ICU每天患者洗的疗效.
评估不同CHG洗方法对皮肤微生物殖民和CHG皮肤度的影响.
评估与医疗保健相关的感染 (HAI),不良反应和与每个CHG洗方法相关的皮肤耐受性.

主要方法:

采用了前性交叉研究设计,涉及两个ICU.
单位在使用2%的CHG布和4%的CHG溶液之间交替使用,每天患者在两个阶段洗.
采集了皮肤拭子,以量化微生物殖民和CHG度,以及对HAI和不良事件的监测.

主要成果:

与没有CHG浴相比,2%的CHG布和4%的CHG溶液都显著减少了微生物皮肤殖民 (P < .001).
与4%的CHG溶液 (1627 CFU/cm2和307.2 ppm) 相比,2%的CHG布料导致显著较低的微生物殖民 (691 CFU/cm2) 和更高的CHG皮肤度 (1300.4 ppm).
这两种浴方法都被很好地容忍,在两组之间没有观察到HAI率的显著差异.

结论:

每天用2%的CHG布或4%的CHG溶液洗有效地减少了ICU患者的微生物皮肤殖民.
2%的CHG布表现出卓越的性能,实现了更高的CHG皮肤度和更显著的微生物负载减少.
这些发现支持使用2%的CHG布作为在ICU中CHG洗的有效方法,以减少微生物殖民.

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