偏爱糖的肠道微生物通过产生外聚糖来防止宿主肥胖
Hidenori Shimizu1,2, Junki Miyamoto3, Keiko Hisa2
1Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto, Japan.
一些肠道细菌,如Streptococcus salivarius,可以通过从糖糖中产生外聚糖 (EPS) 来预防肥胖. 这个EPS短链脂肪酸 (SCFA) 轴影响能源调节,提供潜在的益生菌策略.
科学领域:
- 微生物学 微生物学
- 代谢过程中的代谢.
- 主体微生物群的相互作用
背景情况:
- 交叉体细菌通过碳水化合物代谢影响宿主健康.
- 关联细菌糖代谢与宿主健康,特别是肥胖的确切机制尚未完全理解.
研究的目的:
- 为了确定参与预防肥胖的特定共生细菌.
- 阐明Streptococcus salivarius影响宿主肥胖的机制,重点关注其代谢产品.
主要方法:
- 在小鼠模型中识别Streptococcus salivarius作为一种抗肥胖细菌.
- 分析S. salivarius从各种糖中产生的外聚糖 (EPS).
- 在肥胖和健康的人类捐赠者之间比较S. salivarius丰富度和EPS短链脂肪酸 (SCFA) 途径活性.
主要成果:
- 在雄性小鼠中,S. salivarius表现出抗肥胖作用,与糖糖摄入有关.
- 观察到S. salivarius特别从糖糖中产生高的EPS.
- 在肥胖的捐赠者中发现了减少的S. salivarius丰度和减弱的EPS-SCFA代谢活性.
结论:
- 涉及Streptococcus salivarius的外聚糖 (EPS) - 短链脂肪酸 (SCFA) - 碳水化合物代谢轴在预防饮食引起的肥胖中发挥着作用.
- 葡萄糖代谢中的宿主-共生相互作用对于能量调节至关重要.
- 针对特定的细菌及其代谢物,如EPS,是通过益生菌和益生菌预防生活方式相关疾病的潜在策略.
更多相关视频
00:06Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
Published on: August 23, 2019
12:02Automated Modular High Throughput Exopolysaccharide Screening Platform Coupled with Highly Sensitive Carbohydrate Fingerprint Analysis
Published on: April 11, 2016
相关概念视频
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
Glucose Absorption Into the Small Intestine
Sugars as Energy Storage Molecules
Carbohydrate Absorption
After being swallowed, the partially digested carbohydrates mix with gastric secretions in the stomach. However, the acidic environment...
