在精神分裂症患者中,便细菌和病毒相互作用以及微生物群衍生的功能障碍的改变
Shiwan Tao1,2,3, Yulu Wu1,2, Liling Xiao1,2
1Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Translational psychiatry
|January 29, 2025
概括
精神分裂症 (SCZ) 患者表现出改变的肠道细菌和病毒,破坏正常的相互作用. 这种肠道病毒组-细菌组不平衡影响宿主代谢,可能有助于SCZ病变发生,并提供新的治疗点.
科学领域:
- 微生物组研究 微生物组研究
- 神经精神病学是一种神经精神病学.
- 病毒学 病毒学
背景情况:
- 肠道细菌组的改变越来越多地与精神分裂症 (SCZ) 有关.
- 肠道病毒组在SCZ中影响肠道细菌组的特定作用仍然在很大程度上未被探索.
- 了解这些复杂的相互作用对于阐明SCZ病原性至关重要.
研究的目的:
- 研究SCZ患者肠道病毒组,细菌组和宿主外周代谢组之间的相互作用.
- 为了确定与SCZ相关的特定病毒和细菌特征.
- 探索肠道细菌组和宿主代谢物在肠道病毒组对SCZ的影响中的调解作用.
主要方法:
- 在49名SCZ患者和49名健康对照 (HC) 中,便病毒组,细菌组和宿主外周代谢组的测序.
- 在SCZ和HC之间比较肠道细菌群体的组成和丰度.
- 多重同惯性分析 (MCIA) 用于识别与不同细菌同时存在的病毒和代谢物.
- 潜伏串行调解模型 (SMM) 来评估因果途径.
主要成果:
- 在SCZ患者中,肠道细菌β多样性降低,特定细菌的丰度发生变化 (例如,Coprobacillaceae,Enterococcaceae).
- 发现特定的肠道病毒 (例如,Suoliviridae,Rountreeviridae) 与SCZ相关的细菌同时发生.
- 之前在HC中观察到的病毒-细菌相关性在SCZ患者中显著减少.
- 改变的病毒-细菌相互作用与宿主外周代谢物 (胆酸,eicosanoids) 的变化相关,可能会影响免疫功能.
结论:
- 精神分裂症与异常的肠道病毒-细菌生态有关,其特点是失去跨王国相关性.
- 肠道病毒组似乎通过细菌组和宿主代谢配置文件的调解来影响SCZ病变发生.
- 这些发现突出了针对肠道微生物生态系统的潜力,用于SCZ的新型治疗策略.
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