基于复合炎症指标的基础上,开发和验证重症2型糖尿病患者在ICU中的预后模型
Lin Liu1, Yan-Bo Zhao1, Zhuo-Ting Cheng2
1Department of Emergency and Critical Care Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Scientific reports
|January 29, 2025
概括
八个炎症指标预测了2型糖尿病 (T2DM) 严重病患者的预后. 一种已开发的模型准确地分层风险,并预测了重症监护室 (ICU) 中这些高死亡率患者的结果.
科学领域:
- 关键护理医学 关键护理医学
- 内分泌学 在内分泌学.
- 生物统计学 生物统计学
背景情况:
- 患有2型糖尿病 (T2DM) 的重症患者在重症监护室 (ICU) 面临高死亡风险.
- 确定可靠的预后指标对于管理这些复杂的患者至关重要.
研究的目的:
- 研究9个炎症指标与2型糖尿病重症患者的预后之间的关联.
- 开发和验证一个预测模型来评估ICU环境中的死亡风险.
主要方法:
- 从MIMIC-IV数据库 (培训/测试套件) 中对4783名患有严重T2DM患者进行了回顾性分析.
- 外部验证使用来自中国单中心队列的204名患者.
- 后勤回归,考克斯回归,LASSO回归和多变量后勤回归被用于分析和建模.
主要成果:
- 八个炎症指标与短期预后有显著的相关性 (P <0.05).
- 预后模型显示出优异的区别 (AUC在试验组中为0.825,在外部验证中为0.741).
- 校准曲线和决策曲线分析证实了该模型的一致性和临床实用性.
结论:
- 八个炎症指标是T2DM重症患者预后的独立风险因素.
- 经过验证的预测模型显示了在ICU中早期风险分层和个性化治疗策略的潜力.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
310
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
310
Acute Pancreatitis II: Clinical Manifestations and Management
91
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
91


