海马体内扩大的周血管空间与2型糖尿病患者的记忆功能有关
Peichun Pan1,2, Dongsheng Zhang1, Jing Li1
1Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
Scientific reports
|January 29, 2025
概括
hippocampus (H-EPVS) 中扩大的周血管空间在具有认知障碍的2型糖尿病患者中更为常见. 这一发现表明H-EPVS可能是检测T2DM认知功能障碍的成像标志物.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 内分泌学 在内分泌学.
背景情况:
- 由于治疗选择有限,早期发现2型糖尿病 (T2DM) 的认知功能障碍对于管理至关重要.
- 扩大周血管空间 (EPVS) 与大脑小血管疾病有关,可能会影响认知功能.
- 特别是海马体EPVS (H-EPVS) 可能在T2DM患者观察到的认知衰退中发挥作用.
研究的目的:
- 调查H-EPVS与T2DM患者认知表现之间的关联.
- 确定H-EPVS是否可以作为T2DM认知功能障碍的神经成像生物标志物.
- 探索H-EPVS,淋巴功能和脑小血管疾病 (CSVD) 标志物之间的关系.
主要方法:
- 对66名具有认知障碍的T2DM患者 (T2DM-CI) 和71名具有正常认知功能的T2DM患者 (T2DM-NC) 进行了头骨MRI扫描和综合的神经心理评估.
- 在T2WI成像上,视觉计算H-EPVS计数.
- 部分相关性和多重线性回归分析被用来评估H-EPVS,认知功能,DTI-ALPS指数和CSVD标志物之间的关系.
主要成果:
- 与T2DM-NC患者相比,T2DM-CI患者的总和左侧H-EPVS数量显著增加 (P < 0.001).
- 在T2DM-CI组显示较低的DTI-ALPS指数和RAVLT总得分.
- 总H-EPVS计数与MMSE,即时记忆和延迟回忆得分负相关,与BG-EPVS和CSO-EPVS正相关.
结论:
- 升高的H-EPVS与T2DM患者的认知障碍有关.
- 在T2DM中,H-EPVS可能代表一种潜在的神经成像生物标志物,用于早期检测T2DM认知功能障碍.
- 需要进一步的研究来验证H-EPVS作为可靠的生物标志物.
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