皮内高级糖化最终产品与2型糖尿病的 reduced 坐骨神经结构完整性有关
Christoph M Mooshage1, Dimitrios Tsilingiris2,3,4, Lukas Schimpfle2,3
1Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Clinical neuroradiology
|January 29, 2025
概括
皮肤自发光,是高级糖化最终产品的指标,与2型糖尿病中神经损伤相关. 管理心血管风险对于预防糖尿病神经并发症至关重要,例如远端感官运动性多神经病变.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
背景情况:
- 在2型糖尿病 (T2D) 中严格的血糖控制并不能防止远端感觉运动多神经病变 (DSPN) 的进展.
- 持续高血糖和心血管因素有助于糖尿病相关的神经损伤.
- 皮肤自发光 (sAF) 测量皮肤高级糖化最终产品 (AGE) 积累,反映累积的代谢和血管损伤.
研究的目的:
- 评估SAF,心血管风险和T2D中外围神经完整性之间的相关性.
- 为了研究AGE,动脉硬和神经损伤之间的关系.
- 探索潜在的机制,将血管损伤与DSPN中的神经元损伤联系起来.
主要方法:
- 研究了62名患有T2D的个人和10名健康对照 (HC).
- 扩散张力MRI成像评估了坐骨神经的分数异性质 (FA) 对于神经完整性.
- 评估了sAF,动脉硬 (脉冲波速度,PWV) 和临床/血清学标记.
主要成果:
- 与HC和没有DSPN的人相比,DSPN患者的sAF显著更高.
- 在T2D中,FA与sAF,PWV和高灵敏度托罗邦素T (hsTNT) 有负相关.
- 在DSPN中,sAF与hsTNT和PWV正相关;FA与PWV负相关.
结论:
- 这项研究表明,在T2D中,外围神经完整性降低和AGE沉积/动脉硬之间存在显著的相关性.
- 研究结果表明,与糖化相关的血管损伤和神经元损伤之间存在机械联系.
- 强调心血管风险管理在预防DSPN方面的重要性.
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