在高血压患者中,初始治疗用含有半剂量四倍治疗与标准剂量双疗法 (QUADUAL) 的单片囊:一种随机,盲目的交叉试验
Xiexiong Zhao1, Tao Liu1, Qiong Yang1,2
1Department of Cardiology, The Third Xiangya Hospital of Central South University, Yuelu District, 138 Tongzipo Road, Changsha, 410013, Hunan, China.
BMC medicine
|January 29, 2025
概括
低剂量四重疗法显著降低血压,比标准剂量双重疗法更有效,用于初始高血压治疗. 这两种治疗策略的安全性概况是可比的.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 目前的高血压指南建议双重组合治疗作为初始治疗.
- 以前的研究表明,低剂量四重疗法优于单一疗法.
- 低剂量四重治疗与双重组合治疗的比较疗效仍未确定.
研究的目的:
- 为了比较单片低剂量四重抗高血压疗法与标准剂量双重抗高血压疗法的疗效和安全性.
- 评估在接受初始治疗的轻度至中度高血压患者的血压降低和安全结果.
主要方法:
- 一个随机的,盲目的,交叉试验 (NCT05377203) 涉及90名轻度至中度高血压患者.
- 参与者接受了半剂量四重疗法 (伊尔贝沙坦/美托普罗罗尔/安洛迪平/英达帕米德) 或标准剂量双重疗法 (伊尔贝沙坦/安洛迪平) 单片药.
- 治疗持续了四周,随后是为期两周的洗期和交叉.
主要成果:
- 与标准剂量双疗法相比,半剂量四倍疗法可以显著降低24小时平均血压 (4.72/4.17 mm Hg,P < 0.001).
- 还观察到四重方案的白天,夜间和办公室血压显著降低.
- 在四重疗法中观察到禁食血糖和尿酸的增加,但整体安全性概况是可比的.
结论:
- 用半剂量四倍组合药开始高血压治疗比标准剂量双重治疗更有效降低血压.
- 半剂量四倍疗法的安全性概况与标准剂量双重疗法相比较,表明有利的风险/益处比率.
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