相关实验视频

Updated: May 30, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

对常见细菌感染的抗生素持续时间 - 一个系统的审查

Yin Mo^1,2,3,4,5, Wei Cong Tan¹, Ben S Cooper^4,5

¹Division of Infectious Diseases, University Medicine Cluster, National University Hospital, Singapore, Singapore.

JAC-antimicrobial resistance

|January 30, 2025

概括

较短的抗生素疗程对许多常见的细菌感染有效,支持抗菌素耐药性 (AMR) 管理. 然而,对于严重的感染和在资源不足的环境中,需要更多的研究来优化抗生素的持续时间.

科学领域:

传染性疾病传染性疾病
抗微生物药物管理委员会
临床试验临床试验

背景情况:

减少抗生素持续时间是打击抗菌素耐药性 (AMR) 的关键干预措施.
目前关于常见细菌感染的最佳抗生素持续时间的证据需要对环境,患者群体和条件的差距进行评估.
试验方法需要对潜在的改进进行评估.

研究的目的:

检查现有的关于常见细菌感染抗生素持续时间的证据.
识别有关环境,患者群体和特定传染病的研究缺口.
评估试验方法及其对证据质量的影响.

主要方法:

在MEDLINE和Embase进行了系统的文献搜索,直到2024年7月进行随机试验.
包括的试验比较了不同抗生素在医院和社区环境中的持续时间.
结果进行了叙事综合,并审查了主要的国际指南.

主要成果:

在315项研究中,有85%的研究得出结论,较短的抗生素疗程具有同等效果或不劣.
强有力的证据支持成人细菌鼻炎,社区获得的肺炎,无并发性纤维炎以及某些尿路和腹腔内感染的持续时间更短.
有限的试验集中在严重感染 (例如,血液感染) 或在低收入和中等收入国家 (LMICs) 进行;只有15%的研究具有低偏差风险.

结论:

减少抗生素持续时间是抗生素管理的重要策略,也是一个活跃的研究领域.
较短的抗生素疗程适用于许多细菌感染,但严重感染需要更多的证据.
需要在低收入和中等收入环境中进行进一步的研究,以确定最佳的抗生素持续时间.

更多相关视频

Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung

Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung

Published on: January 22, 2021

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Published on: March 24, 2023

相关概念视频

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

Pulmonary Tuberculosis V

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...

Antibiotic Selection

Antibiotic Selection

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...