在患有自闭症谱系障碍的儿童中,执行功能,边缘电路动力学以及重复和受限制的行为
Xiangyu Zheng1, Xinyue Wang1, Ruochen Song2
1Peking University Sixth Hospital, Peking University Institute of Mental Health, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), NHC Key Laboratory of Mental Health (Peking University), Beijing, China.
Frontiers in neuroscience
|January 30, 2025
概括
执行功能 (EF) 调解了轨道前皮层 (OFC) 连接和自闭症谱系障碍 (ASD) 中的重复行为之间的联系. 这一发现为ASD提供了新的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 重复和限制行为 (RRBs) 是自闭症谱系障碍 (ASD) 的核心症状.
- 执行功能 (EF) 缺陷与RRB有关,但神经机制尚不清楚.
- 轨道前皮层 (OFC) 涉及EF和RRB,这表明其连接动态至关重要.
研究的目的:
- 调查OFC与ASD中的RRB相关的功能连接 (FC) 的时间变化动态.
- 探索EF在OFC连接和RRB之间的关系中扮演的调解角色.
- 为了确定在ASD中解决RRB的干预措施的潜在神经目标.
主要方法:
- 来自ABIDE II数据库的93名自闭症男孩和110名典型发育 (TD) 男孩的休息状态fMRI数据的分析.
- 在八个OFC子区域和其他大脑区域之间计算时间变化的FC.
- 线性回归和调解分析 (bootstrapping) 来评估连接动态和EF对RRB的影响.
主要成果:
- 在ASD和TD组之间发现了FC变异的显著差异,特别是在OFC-left前额前额和OFC-left杏仁体连接中.
- OFC-桃体FC和EF缺陷的变异增加是RRB的显著预测因素,抑制,情绪控制和监测显示出强烈的关联.
- EF显著调解了非典型的OFC-杏仁体连接动态和RRB之间的关系,占总影响的59%.
结论:
- 执行职能是调解非典型的OFC-杏仁体电路动态对ASD中RRB的影响的关键机制.
- 针对EF赤字可能是一个有希望的治疗策略,用于减少ASD患者的RRB.
- 了解OFC功能连接动态为ASD症状的神经支提供了新的见解.
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