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探索使用F-18 PSMA-1007 PET/MRI检测到原发性前列腺癌多个参数之间的相关性,以及它们预测转移的潜力

Sunpob Cheewadhanaraks¹, Karun Sereeborwornthanasak², Dheeratama Siripongsatian¹

¹National Cyclotron and PET Centre, Chulabhorn Hospital, 906 Kamphaeng Phet 6 Rd., Talat Bang Khen, Lak Si, Bangkok, 10210 Thailand.

Nuclear medicine and molecular imaging

|January 30, 2025

概括

-18 PSMA-1007 PET/MRI定量参数,包括明显扩散系数 (ADC) 和PSMA吸收值,显示与前列腺癌 (PCa) 转移有很强的相关性. 这些参数,特别是PSMA-TLU/ADC和PSMA-TV/ADC的比率,有效地预测PCa转移的存在和程度.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
医疗成像医学成像

背景情况:

前列腺癌 (PCa) 评估受益于先进的成像技术.
前列腺特异性膜抗原 (PSMA) 位子发射断层扫描/磁共振成像 (PET/MRI) 与传统的MRI (cMRI) 相比,提供更好的诊断能力.

研究的目的:

评估由-18 (F-18) PSMA-1007 PET/MRI 在前列腺癌 (PCa) 中获得的定量参数的相关性.
评估这些定量参数在PCa患者中检测转移的预测潜力.

主要方法:

对51名接受F-18 PSMA-1007 PET/MRI的PCa患者的回顾性分析.
在初级瘤中计算表面扩散系数 (ADC),最大标准化吸收值 (SUVmax),PSMA总损伤吸收 (PSMA-TLU) 和PSMA总体积 (PSMA-TV).
ADC与其他参数之间的相关性分析,与接收器运行特征 (ROC) 曲线分析来确定转移的预测截止值.

主要成果:

表面扩散系数 (ADC) 与SUVmax,PSMA-TLU和PSMA-TV (p < 0.0001到0.0050) 呈现出反向相关性.
较低的ADC值和较高的SUVmax,PSMA-TLU和PSMA-TV显著与转移性疾病相关 (p <0.001至0.033).
PSMA-TLU/ADC和PSMA-TV/ADC显示了淋巴结转移的最高预测准确度 (灵敏度:77.78%-100%;特异性:71.43%-89.29%).

结论:

F-18 PSMA-1007 PET/MRI定量参数,特别是涉及ADC的比率,提高了初级PCa病变的诊断准确度.
ADC,PSMA吸收参数和转移性疾病之间的强烈相关性为这种成像模式提供了重要的预后价值.
这种方法有望改善前列腺癌传播的检测和特征.

关键词:

在F-18 PSMA-1007 PET/MRI中使用.转移转移转移转移前列腺癌是什么意思前列腺癌是什么意思定量参数定量参数定量参数

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