急性压力会引发人类小肠微生物组合的性别依赖的快速变化
Bruno K Rodiño-Janeiro1,2, Olfat Khannous-Lleiffe3,4, Marc Pigrau1,2,5
1Laboratory of Neuro-Immuno-Gastroenterology, Digestive System Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Frontiers in microbiology
|January 30, 2025
概括
急性压力迅速改变肠道细菌,特别是在女性中,这可能解释了女性的肠-大脑相互作用 (DGBI) 的消化系统障碍率更高. 这项研究研究了小肠微生物群的压力诱导的变化.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 神经科学是一个神经科学.
背景情况:
- 肠-大脑相互作用 (DGBI) 的消化系统障碍很常见,特别是在女性中,并且与肠道功能障碍和压力有关.
- 以前的研究表明,女性更容易受到压力诱导的肠道屏障功能障碍.
- 压力对小肠微生物群的影响,特别是在女性身上,仍然不清楚.
研究的目的:
- 为了研究小肠微生物群的急性压力诱导的变化.
- 为了确定压力是否对肠道微生物群产生不同性别的影响.
- 了解微生物群变化与应激反应之间的关系.
主要方法:
- 在基线和经过感冒疼痛或假压力后,从健康受试者身上收集了Jejunal活检.
- 监测了自主,荷尔蒙和心理应激反应.
- 16S元编码分析了活检中的微生物DNA,以评估多样性和组成.
主要成果:
- 感冒疼痛压力显著降低了微生物α多样性,女性的影响更为明显.
- 显著的性别差异在微生物种群丰富度和整体组成后压力观察到.
- 微生物群的变化与心理,荷尔蒙和基因表达的变化相关.
结论:
- 急性压力会在健康个体中快速改变头细菌的组成.
- 这些由压力引起的微生物群变化在女性中更为明显.
- 这些发现可能有助于解释DGBI在女性中的更高患病率.
相关概念视频
Irritable Bowel Syndrome I: Introduction
240
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
240
Anatomy of the Intestines
71.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.3K
Introduction to Stress and Lifestyle
73
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
73


