在接受CT指导骨活检的乳腺癌患者中CT纹理分析:与基因病理学的相关性
Silvio Wermelskirchen1, Jakob Leonhardi1, Anne-Kathrin Höhn2
1Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.
Breast cancer : basic and clinical research
|January 30, 2025
概括
计算机断层扫描 (CT) 纹理分析可以帮助预测乳腺癌 (BC) 活检结果和免疫组织化学亚型. 这些成像标记可能会改善BC患者接受骨活检的临床决策.
科学领域:
- 放射学和瘤学 放射学和瘤学
- 医学成像分析 医学成像分析
- 乳腺癌的诊断 乳腺癌的诊断
背景情况:
- 计算机断层扫描 (CT) 引导的皮肤穿骨活检对于鉴定乳腺癌 (BC) 患者骨转移的特征至关重要.
- 对CT图像的纹理分析提供了潜在的定量成像标记,以预测活检结果和瘤特征.
研究的目的:
- 研究CT纹理特征与BC患者的活检结果之间的关系.
- 评估纹理分析在预测乳腺癌骨转移的免疫组织化学 (IHC) 亚型方面的潜力.
主要方法:
- 对66名BC患者进行CT指导的皮肤穿骨活检的回顾性分析.
- 包括临床,成像特征和CT纹理分析.
- 后勤回归分析用于预测负面的活检结果.
主要成果:
- 临床模型显示,活检结果为0.73的预测准确度 (AUC).
- 特定的CT纹理特征,如"WavEnHH_s-3" (P=.002),将光线A与光线B癌症区分开来.
- 其他特征,如"S(5,5) SumVarnc" (P=.01),可以区分三阴性和非三阴性癌症.
结论:
- CT纹理特征可以增强BC骨转移的表征.
- 纹理分析显示了准确预测IHC亚型的潜力.
- 确定CT纹理参数可能有助于临床决策,并识别有负面活检结果风险的患者.
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