中年女性血红蛋白度与心脏代谢风险之间的关联
Tazuko Tokugawa1, Akihiro Sawada1, Satoshi Higasa1
1Department of Respiratory Medicine and Hematology, School of Medicine, Hyogo Medical University, Nishinomiya, Japan.
中年妇女的高血红蛋白水平与心脏代谢风险因素的增加有关,即使没有多细胞血症. 这表明血红蛋白升高可能表明心血管风险较高.
科学领域:
- 心血管健康 心血管健康
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
背景情况:
- 多细胞血症与血栓动脉样硬化疾病有关.
- 高血红蛋白水平与女性心脏代谢风险之间的关系尚未得到充分证实.
研究的目的:
- 研究中年妇女血红蛋白水平和心脏代谢风险因素之间的关联.
- 要确定血红蛋白升高,即使在正常范围内,是否与心血管风险增加有关.
主要方法:
- 一项对18410名接受健康检查的中年女性进行的横截面研究.
- 根据血红蛋白水平,被试被分为四分之一.
- 排除低血红蛋白或有贫血病史的个体.
主要成果:
- 多细胞血症 (血红蛋白>16.0 g/dL) 的患病率为0.14%.
- 较高的血红蛋白四分位数显著增加了体重指数,腰与身高的比,血压,甘油三,LDL胆固醇和血红蛋白A1c.
- 对于高的LDL/HDL比率,脂质积累产物,心脏代谢指数和最高血红蛋白四分位数中的代谢综合征,观察到较高的几率比率.
结论:
- 尽管多细胞血症的患病率较低,但血红蛋白水平较高与心脏代谢风险增加有关.
- 中年妇女正常高血红蛋白水平可能表明心血管风险升高.
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