与动物性禽流感相关的准备,预防和控制
, , Julio Alvarez1
1EFSA Panel on Animal Health and Animal Welfare members.
EFSA journal. European Food Safety Authority
|January 30, 2025
概括
禽流感病毒 (AIV) 通过特定突变适应哺乳动物. 在AIV中监测这些适应性特征对于检测动物感染风险和实施控制措施至关重要.
科学领域:
- 病毒学 病毒学
- 动物传染病研究研究.
- 公共卫生 公共卫生
背景情况:
- 禽流感 (AI) 构成动物传播的威胁,需要了解其感染哺乳动物的潜力.
- 与哺乳动物适应相关的病毒突变是动物感染风险的关键指标.
研究的目的:
- 开发禽流感 (AI) 动物感染潜力的风险评估框架.
- 识别和跟踪与哺乳动物适应AI病毒 (AIVs) 相关的突变.
主要方法:
- 查34个与哺乳动物适应的五个表型特征相关的突变的病毒序列.
- 审查哺乳动物溢出事件和人类血清流行研究.
- 分析适应性突变的地理,时间和亚型特定趋势.
主要成果:
- 具有多种适应性特征的AIV在低致病性和高致病性亚型中被发现,主要在亚洲 (例如,A(H9N2),A(H7N9).
- 在欧盟/欧洲经济区,H5Nx病毒显著获得了动物病特征.
- 增强的聚合酶活性和免疫逃避是常见的适应性特征;受体特异性突变很少见. 人类病例仍然不常见,但与具有适应性特征的亚型有关.
结论:
- 哺乳动物对AIVs的适应是由病毒,宿主和外部暴露因素驱动的.
- 对动物和人类进行全面的基因组监测对于早期动物性AI病毒检测至关重要.
- 一个健康的方法,包括加强监测和全球合作,对于减轻动物传播的风险至关重要.
关键词:
禽流感是禽流感的一种疾病.鸟类 鸟类 鸟类 鸟类 鸟类高致病性禽流感 (HPAI) 是一种高度致病性禽流感.哺乳动物 哺乳动物突变是发生在突变中的突变.准备工作 准备工作 准备工作公共卫生公共卫生.更多相关视频
07:15Preparation of Pseudo-Typed H5 Avian Influenza Viruses with Calcium Phosphate Transfection Method and Measurement of Antibody Neutralizing Activity
Published on: November 22, 2021
2.2K
12:09Avian Influenza Surveillance with FTA Cards: Field Methods, Biosafety, and Transportation Issues Solved
Published on: August 2, 2011
19.2K
相关概念视频
Viral Mutations
32.1K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.1K
Steps in Outbreak Investigation
102
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
102
Viral Recombination
23.2K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.2K
Infection
7.5K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.5K
Transmission-based Precautions I: Contact, Enteric, and Droplets
3.3K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
3.3K
Transmission-based Precautions II: Airborne and Protective Environment
1.2K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.2K
