激素诱导的红细胞瘤的患病率和预测因素:一个回顾性单中心研究
Anina Neidhart1, Viktor von Wyl2,3, Benno Käslin4
1Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, Luzerner Kantonsspital, Lucerne, Switzerland.
Frontiers in endocrinology
|January 30, 2025
概括
替代疗法 (TRT) 经常导致诱导的红细胞瘤 (TIE). 基线BMI和血红素水平预测TIE风险,需要在TRT期间密切监测.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 安德罗学与人类学
背景情况:
- 替代疗法 (TRT) 广泛用于治疗低性.
- 诱导的红细胞瘤 (TIE) 是TRT的已知副作用.
- 了解TIE患病率和预测因素对于患者安全至关重要.
研究的目的:
- 在接受TRT的患者中分析激素诱导的红细胞瘤 (TIE) 的患病率.
- 确定与TIE发展相关的预测因素.
主要方法:
- 回顾性单中心观察性研究.
- 包括接受TRT的247名患者.
- 对血红素水平 (HCT) 和相关因素 (如BMI和基线HCT) 的分析.
主要成果:
- 在TRT期间观察到HCT值的显著增加.
- 57%的患者达到HCT>0.46,23%的患者达到>0.5.5.
- 后勤回归确定了基线BMI和基线HCT作为HCT升高的显著预测因素.
结论:
- 诱导的红细胞炎 (TIE) 在接受TRT的患者中很常见.
- 基线BMI和HCT对于TIE风险分层很重要.
- 建议对实验室进行密切监测,特别是在第一年内,随后进行年度检查.
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