SARS-CoV-2 CoCoPUTs:分析GISAID和NCBI数据,在多年时间内获得子统计,突变和自由能量

Nigam H Padhiar1, Tigran Ghazanchyan2, Sarah E Fumagalli1

  • 1Hemostasis Branch 1, Division of Hemostasis, Office of Plasma Protein Therapeutics CMC, Office of Therapeutic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.

Virus evolution
|January 30, 2025
PubMed
概括

一个名为SARS-CoV-2 CoCoPUTs的新数据库汇编了严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 变种的编码子使用,突变和RNA二次结构数据. 这项分析揭示了病毒演变的趋势,包括非同名突变的增加和同名突变在RNA稳定性中的作用.

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