关于NT-pro BNP对患有心室隔膜缺陷手术的儿童结果的预测值

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概括

在接受腹腔隔膜缺陷 (VSD) 手术的儿童中,手术前较高的NT-proBNP水平与更长的住院时间相关. 手术后的NT-proBNP水平没有预测儿科VSD患者的临床结果.

科学领域:

儿童心脏病学儿童心脏病学
在先天性心脏病中的生物标志物.
手术结果研究研究.

背景情况:

关于NT-proBNP在儿科心室隔膜缺陷 (VSD) 手术中的预后价值的研究有限.
NT-proBNP是心脏压力的生物标志物,但其在VSD手术结果中的预测作用需要澄清.

研究的目的:

评估NT-proBNP对接受VSD手术的儿童临床结果的预测价值.
为了确定手术前和手术后的NT-proBNP水平是否与VSD修复后的短期和中期结果相关.

主要方法:

一组798名接受VSD手术的儿童在手术前和手术后24小时测量了NT-proBNP水平.
倾向性得分匹配被用来创建可比的队列来分析NT-proBNP水平的影响.
记录了短期和中期的临床结果,包括住院时间,机械通风,心肺绕道时间,CCU停留时间和喷射分数.

主要成果:

在手术前的NT-proBNP匹配队列中,较高的水平与更长的住院时间和更低的1个月射出分数 (EF) 有关.
根据手术前的NT-proBNP水平,在机械通风,CPB时间,CCU停留时间或3-12个月后的EF中没有发现显著差异.
手术后的NT-proBNP水平与机械呼吸,CPB时间,CCU停留时间,住院时间或1至12个月的EF没有显著的关联.

结论:

儿科VSD患者手术前NT-proBNP水平升高预测了手术后住院时间的延长.
手术前的NT-proBNP水平似乎不会影响机械通风,CPB时间,CCU停留时间或VSD修复后的长期心脏功能.
24小时后的术后NT-proBNP水平与VSD手术后儿童的临床结果无关.

关键词:

NT-亲 BNPNT-亲BNP 的国家.孩子们的孩子们的孩子们的孩子们临床结果的临床结果.预测价值是一个预测值.腹腔隔膜缺陷腹腔隔膜缺陷

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